My Sister's Keeper Cast: Abigail Breslin as Anna Fitzgerald

Abigail Breslin (Anna Fitzgerald) earned an Academy Award nomination as well as BAFTA and Screen Actors Guild Award nominations and a Best Actress Award from the Tokyo International Film Festival, and was named 2008's ShoWest Female Star of Tomorrow for her performance as an ambitious young girl obsessed with winning a beauty pageant in the critically acclaimed, irreverent comedy "Little Miss Sunshine.”

One of the most versatile and sought-after actresses of her generation, Breslin is set to voice characters in three animated features: this year's "Quantum Quest: A Cassini Space Odyssey,” starring Chris Pine, Amanda Peet and Samuel L. Jackson; Gore Verbinski's "Rango,” opposite Johnny Depp and Isla Fisher; and "The Wild Bunch,” with Willem Dafoe and Chris Klein. Breslin can be seen later this year alongside Woody Harrelson, Jesse Eisenberg, Emma Stone and Mila Kunis in the upcoming live action horror-comedy "Zombieland.”

Breslin recently starred in Scott Hicks' "No Reservations,” with Catherine Zeta-Jones and Aaron Eckhart; in Adam Brooks' romantic comedy "Definitely, Maybe,” with Elizabeth Banks, Rachel Weisz and Ryan Reynolds; in the title role of "Kit Kittredge: An American Girl”; and as Nim in the family adventure "Nim's Island,” opposite Jodie Foster and Gerard Butler.

Previously, Breslin starred with Mel Gibson in M. Night Shyamalan's "Signs,” and in "Raising Helen,” for director Garry Marshall, opposite her older brother Spencer Breslin and Kate Hudson. She appeared in the independent drama "Keane,” directed by Lodge Kerrigan and produced by Steven Soderbergh; in "The Ultimate Gift,” co-starring James Garner; and in "The Santa Clause 3: The Escape Clause.”

On television, Breslin has guest-starred on "Law & Order: Special Victims Unit,” "N.C.I.S.,” "What I Like About You,” "Ghost Whisperer” and "Grey's Anatomy.”

Other Cast

Toni Collette Shirley MacLaine Mark Feuerstein Curtis Hanson