1	Pirates of the Caribbean 2 Buena Vista Pictures $423,271,331	2	Night at the Museum 20th Century Fox $250,863,268	3	Cars Buena Vista Pictures $244,082,982

Rank	Title	Studio	Box Office
1.	Pirates of the Caribbean: Dead Man's Chest	Buena Vista	$423,271,331
2.	Night at the Museum	20th Century Fox	$250,863,268
3.	Cars	Buena Vista	$244,082,982
4.	X-Men: The Last Stand	20th Century Fox	$234,362,462
5.	The Da Vinci Code	Sony Pictures	$217,536,138
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6.	Superman Returns	Warner Bros.	$200,081,192
7.	Happy Feet	Warner Bros.	$198,000,317
8.	Ice Age: The Meltdown	20th Century Fox	$195,330,621
9.	Casino Royale	Sony Pictures	$167,445,960
10.	The Pursuit of Happyness	Sony / Columbia	$163,566,459
11.	Over the Hedge	DreamWorks	$155,019,340
12.	Talladega Nights: The Ballad of Ricky Bobby	Sony Pictures	$148,213,377
13.	Click	Sony / Revolution	$137,340,146
14.	Mission: Impossible III	Paramount	$134,029,801
15.	The Departed	Warner Bros.	$132,373,442
16.	Borat	20th Century Fox	$128,503,736
17.	The Devil Wears Prada	20th Century Fox	$124,740,460
18.	The Break-Up	Universal	$118,703,275
19.	Dreamgirls	Paramount	$102,882,170
20.	Scary Movie 4	Dimension	$90,710,620
21.	Failure to Launch	Paramount	$88,715,192
22.	Inside Man	Universal	$88,513,495
23.	The Santa Clause 3: The Escape Clause	Buena Vista	$84,381,713
24.	Open Season	Sony / Columbia	$84,303,558
25.	Charlotte's Web	Paramount	$82,506,325
26.	The Pink Panther	Sony Pictures	$82,226,474
27.	Eight Below	Buena Vista	$81,612,565
28.	Saw III	Lionsgate	$80,238,724
29.	Nacho Libre	Paramount	$80,197,993
30.	You, Me and Dupree	Universal	$75,628,110
31.	Eragon	20th Century Fox	$74,931,900
32.	Monster House	Sony Pictures	$73,661,010
33.	Barnyard: The Original Party Animals	Paramount	$72,637,803
34.	Jackass: Number Two	Sony Pictures	$72,778,712
35.	R.V.	Sony Pictures	$71,726,025
36.	V for Vendetta	Warner Bros.	$70,511,035
37.	World Trade Center	Paramount	$70,278,893
38.	Rocky Balboa	20th Century Fox	$70,261,813
39.	Big Momma's House 2	20th Century Fox	$70,165,972
40.	Step Up	Buena Vista	$65,328,121
41.	Miami Vice	Universal	$63,450,470
42.	Madea's Family Reunion	Lionsgate	$63,257,940
43.	Deja Vu	Buena Vista	$63,112,228
44.	The Holiday	Sony / Columbia	$62,889,000
45.	The Fast and the Furious: Tokyo Drift	Universal	$62,514,415
46.	Underworld: Evolution	Screen Gems	$62,318,875
47.	The Shaggy Dog	Buena Vista	$61,123,569
48.	Poseidon	Warner Bros.	$60,674,817
49.	Flushed Away	DreamWorks	$60,042,437
50.	Little Miss Sunshine	Fox Searchlight	$59,887,868